44+ Drug Induced Megaloblastic Anemia US. Megaloblastic anemia is a type of anemia , a blood disorder in which the number of red blood cells is lower than normal. Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis.
Megaloblastic anemia mak from image.slidesharecdn.com When dna synthesis is impaired, the cell cycle cannot progress from the g2 growth stage to the mitosis (m) stage. Megaloblastic (pernicious) anemia results from a lack of intrinsic factor in gastric secretions (a substance needed to absorb vitamin b12 from the gastrointestinal tract). Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis.
The most common causes are folate (vitamin b9) deficiency and cobalamin (vitamin b12) deficiency.
The anemia is reversed by pyroxidine or by withdrawal of isoniazid. Extensive intestinal resection, resection of jejunum. Failure of dna synthesis results in asynchrony between the maturation of the nucleus and cytoplasm of the hematopoietic cells. Deficiency of enzymes necessary for the metabolism of folic acid
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